血流动力学变化对自由活动大鼠下丘脑后部牛磺酸释放的影响。
Effects of hemodynamic changes on taurine release from posterior hypothalamus of freely moving rats.
作者信息
Guo L J, Athineos P
机构信息
Institute of Pharmacology and Toxicology, Innsbruck University, Austria.
出版信息
Zhongguo Yao Li Xue Bao. 1995 Sep;16(5):405-8.
AIM
To study the effects of blood volume and vascular resistance on taurine release.
METHODS
We used push-pull superfusion technique in the posterior hypothalamus of conscious freely moving rats. Taurine was determined in the superfusate by HPLC with fluorescence detection following automatic precolumn o-phthaldialdehyde (OPA) derivatization.
RESULTS
Hypervolemia increased the release of taurine in the hypothalamus. Intravenous infusion of levarterenol (3 micrograms kg-1 min-1) elicited a pronounced pressor response and an increase in the release of taurine. Conversely, a controlled hemorrhagic hypotension or iv infusion of nitroprusside (30 micrograms kg-1 min-1) elicited a hypotension and a decrease in the release of taurine from the posterior hypothalamus.
CONCLUSION
In the posterior hypothalamus, taurine might play an important role in central blood pressure regulation.
目的
研究血容量和血管阻力对牛磺酸释放的影响。
方法
我们在清醒自由活动大鼠的下丘脑后部采用推挽式超灌注技术。通过高效液相色谱法（HPLC），在自动柱前邻苯二甲醛（OPA）衍生化后用荧光检测法测定超滤液中的牛磺酸。
结果
血容量过多会增加下丘脑牛磺酸的释放。静脉输注去甲肾上腺素（3微克/千克·分钟）引起明显的升压反应，并使牛磺酸释放增加。相反，控制性出血性低血压或静脉输注硝普钠（30微克/千克·分钟）引起低血压，并使下丘脑后部牛磺酸释放减少。
结论
在下丘脑后部，牛磺酸可能在中枢血压调节中起重要作用。
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