Kikuta K, Yasue H, Yoshimura M, Morita E, Sumida H, Kato H, Kugiyama K, Ogawa H, Okumura K, Ogawa Y, Nakao K
Division of Cardiology, Kumamoto University School of Medicine, Kumamoto, Japan.
Am Heart J. 1996 Jul;132(1 Pt 1):101-7. doi: 10.1016/s0002-8703(96)90396-8.
This study was designed to examine the plasma levels of B-type or brain natriuretic peptide (BNP), as well as A-type or atrial natriuretic peptide (ANP) in patients with unstable angina as compared with those in patients with stable exertional angina and control subjects. We measured the plasma levels of BNP and ANP in 33 patients with unstable angina, 20 patients with stable exertional angina, and 20 control subjects. The plasma levels of BNP were significantly increased in patients with unstable angina compared with those in patients with stable exertional angina and control subjects, respectively (39.5 +/- 29.4 pg/ml vs 15.1 +/- 8.0 pg/ml; p < 0.01 and 39.5 +/- 29.4 pg/ml vs 10.3 +/- 6.4 pg/ml; p < 0.01, respectively). On the other hand, there was no significant difference in the plasma levels of ANP among the three groups. Furthermore, in patients with unstable angina, the plasma levels of BNP decreased significantly after the medical treatment (from 39.5 +/- 29.4 pg/ml to 15.8 +/- 11.0 pg/ ml; p < 0.01), whereas the plasma levels of ANP did not change. We conclude that the plasma levels of BNP are increased in the majority of patients with unstable angina and that the increased levels decrease toward normal after treatment.
本研究旨在检测不稳定型心绞痛患者血浆B型或脑钠肽（BNP）以及A型或心钠素（ANP）水平，并与稳定型劳力性心绞痛患者及对照者进行比较。我们测定了33例不稳定型心绞痛患者、20例稳定型劳力性心绞痛患者和20例对照者的血浆BNP和ANP水平。与稳定型劳力性心绞痛患者及对照者相比，不稳定型心绞痛患者的血浆BNP水平显著升高（分别为39.5±29.4 pg/ml对15.1±8.0 pg/ml；p<0.01和39.5±29.4 pg/ml对10.3±6.4 pg/ml；p<0.01）。另一方面，三组间ANP血浆水平无显著差异。此外，不稳定型心绞痛患者经药物治疗后，血浆BNP水平显著下降（从39.5±29.4 pg/ml降至15.8±11.0 pg/ml；p<0.01），而血浆ANP水平未改变。我们得出结论，大多数不稳定型心绞痛患者血浆BNP水平升高，且治疗后升高的水平下降至正常。
