Arad M, Elazar E, Shotan A, Klein R, Rabinowitz B
Heart Institute, Sheba Medical Center, Tel-Hashomer, Israel.
Cardiology. 1996 Jan-Feb;87(1):12-7. doi: 10.1159/000177053.
The objective of the study was the evaluation of natriuretic peptides in ischemic heart disease. Atrial and brain peptides (ANP, BNP) were elevated in patients with ischemic heart failure, as compared with patients with angina without over failure, and controls (p < 0.01). BNP/ANP ratio was higher in NYHA class IV than in class III patients (2.67 +/- 0.87 vs. 1.52 +/- 0.59, respectively). Patients in the angina group, in whom elevated BNP or ANP was found, had subclinical systolic or diastolic dysfunction. There was inverse correlation between BNP, ANP and the left-ventricular ejection fraction (each r = 0.78, p < 0.001). We conclude that BNP is elevated as a result of myocardial dysfunction, but not of ischemia and seems to be a better index of disease stage and prognosis than ANP.
该研究的目的是评估缺血性心脏病中利钠肽的情况。与无心力衰竭的心绞痛患者及对照组相比，缺血性心力衰竭患者的心房肽和脑肽（ANP、BNP）水平升高（p<0.01）。纽约心脏协会（NYHA）IV级患者的BNP/ANP比值高于III级患者（分别为2.67±0.87和1.52±0.59）。在心绞痛组中，发现BNP或ANP升高的患者存在亚临床收缩或舒张功能障碍。BNP、ANP与左心室射血分数之间呈负相关（r均为0.78，p<0.001）。我们得出结论，BNP升高是心肌功能障碍所致，而非缺血所致，并且似乎是比ANP更好的疾病分期和预后指标。
