Tsuchiya T, Suzuki O, Igarashi K
Department of Bioproduction, Faculty of Agriculture, Yamagata University, Japan.
Biosci Biotechnol Biochem. 1996 May;60(5):765-8. doi: 10.1271/bbb.60.765.
The protective effects of chlorogenic acid on paraquat-induced oxidative stress were examined in rats. The activities of erythrocytes and liver glutathione peroxidase, and of both liver catalase and glutathione reductase, which were increased by feeding paraquat, declined to the levels in the control rats by supplementing chlorogenic acid to the paraquat diet. The activity of superoxide dismutase was not changed by dietary paraquat or by supplementing chlorogenic acid to the paraquat diet. Paraquat in the diet markedly decreased the liver triacylglycerol and phospholipid concentrations, as well as the food intake and body weight gain, while chlorogenic acid protected against these decreases. These in vivo results and the in vitro superoxide anion scavenging activity of chlorogenic acid suggest that chlorogenic acid acted preventively against paraquat-induced oxidative stress.
研究了绿原酸对百草枯诱导的大鼠氧化应激的保护作用。喂食百草枯后增加的红细胞和肝脏谷胱甘肽过氧化物酶活性，以及肝脏过氧化氢酶和谷胱甘肽还原酶活性，通过在百草枯饮食中补充绿原酸而降至对照大鼠的水平。饮食中的百草枯或在百草枯饮食中补充绿原酸均未改变超氧化物歧化酶的活性。饮食中的百草枯显著降低了肝脏三酰甘油和磷脂浓度，以及食物摄入量和体重增加，而绿原酸可防止这些降低。这些体内结果以及绿原酸的体外超氧阴离子清除活性表明，绿原酸对百草枯诱导的氧化应激具有预防作用。
