School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
J Photochem Photobiol B. 2014 Jan 5;130:293-8. doi: 10.1016/j.jphotobiol.2013.11.020. Epub 2013 Dec 2.
The mammalian skin is prone to oxidative damage when exposed to ultraviolet (UV) rays from the sun light. The antioxidants like chlorogenic acid (CA) can protect the skin from the ill effects of UV radiation when applied topically. But conventional topical formulations of these phytomolecules could not protect the skin for long duration owing to their rapid distribution in the systemic circulation. Therefore the aim of the present investigation was to prepare a novel topical formulation of CA which can exert its protective effect for long time after its application. The phospholipid complex of the CA was prepared and evaluated against oxidative stress produced in the rat skin due to UVA exposure. Compared to the conventional formulation, the complex exerted improved protection when UVA irradiation was performed after 4h of topical application. Thus the results ascertain the superiority of CA-phospholipid complex over conventional formulation in terms of protection against UVA radiation for long duration.
哺乳动物的皮肤在暴露于阳光中的紫外线（UV）时容易受到氧化损伤。抗氧化剂，如绿原酸（CA），可以通过局部应用来保护皮肤免受 UV 辐射的不良影响。但是，由于这些植物分子的常规局部制剂会迅速分布在全身循环中，因此不能长时间保护皮肤。因此，本研究的目的是制备一种新型 CA 局部制剂，使其在应用后能长时间发挥保护作用。制备了 CA 的磷脂复合物，并对其进行了评估，以对抗 UVA 暴露引起的大鼠皮肤氧化应激。与常规制剂相比，在局部应用 4 小时后进行 UVA 照射时，该复合物表现出更好的保护作用。因此，结果证实 CA-磷脂复合物在长时间保护 UVA 辐射方面优于常规制剂。
