Arushanian E B, El'bek'ian K S
Eksp Klin Farmakol. 1995 Nov-Dec;58(6):14-6.
Chronic administration of depressants of various classes in rats and a single administration of reserpine result in changes in catecholamine exchange in both hypothalamus and adrenal glands. Antidepressants prevent from a sharp decrease in level of hypothalamic dofamine, induced with reserpine. The importance of central dofaminergic mechanisms for specific effect of compounds is emphasized.
对大鼠长期施用各类抑制剂以及单次施用利血平会导致下丘脑和肾上腺中儿茶酚胺交换的变化。抗抑郁药可防止利血平诱导的下丘脑多巴胺水平急剧下降。强调了中枢多巴胺能机制对化合物特定作用的重要性。
