Maĭorov D N, Murashev A N, Medvedev O S
Eksp Klin Farmakol. 1995 Nov-Dec;58(6):19-21.
A hypotensive effect of clonidine in non-narcotized intact and aorta baro-denervated rats is studied under conditions of minimization of stress actions (radiotelemetry) and under standard conditions of direct recording arterial pressure (AP). Direct AP recording is shown to determine an increase in background AP in baro-denervated rats, but not in control rats. An increase in background AP level under conditions of direct recording is not accompanied with decreasing hypotensive effect of clonidine in baro-denervated rats.
在将应激作用降至最低（无线电遥测）的条件下以及在直接记录动脉血压（AP）的标准条件下，研究了可乐定对未麻醉的完整大鼠和主动脉压力感受器去神经大鼠的降压作用。结果显示，直接记录动脉血压可确定压力感受器去神经大鼠的基础动脉血压升高，但对照大鼠未出现这种情况。在直接记录条件下基础动脉血压水平的升高，并未伴随可乐定对压力感受器去神经大鼠降压作用的减弱。
