Murashev A N, Kunduzova O R, Khokhlova O N, Medvedeva N A, Medvedev O S
Eksp Klin Farmakol. 1997 Jul-Aug;60(4):32-4.
Radiotelemetric monitoring of hemodynamic parameters was conducted in Wistar rats to study the chronobiological dependence of the effect of clonidine on changes in arterial pressure (AP) and heart rate (HR) induced by immobilization stress. Clonidine injection (20 mg/kg intraperitoneally) caused significant decrease in AD at night both at rest and under stress, whereas at day time its hypotensive effect was manifested only in case of immobilization. The negative cardiochronotropic effect of clonidine was also time-dependent. Thus, chronobiological dependence of the clonidine effects at rest and under stress was disclosed.
对Wistar大鼠进行血流动力学参数的无线电遥测监测，以研究可乐定对固定应激诱导的动脉血压（AP）和心率（HR）变化的影响的时间生物学依赖性。腹腔注射可乐定（20mg/kg）导致夜间静息和应激状态下动脉血压均显著降低，而在白天，其降压作用仅在固定应激时出现。可乐定的负性变时作用也具有时间依赖性。因此，揭示了可乐定在静息和应激状态下作用的时间生物学依赖性。
