Gaziev D, Baronciani D, Galimberti M, Polchi P, Angelucci E, Giardini C, Muretto P, Perugini S, Riggio S, Ghirlanda S, Erer B, Maiello A, Lucarelli G
Divisione Ematologica e Centro Trapianto Midollo Osseo di Muraglia, Ospedale di Pesaro, Italy.
Bone Marrow Transplant. 1996 Mar;17(3):409-14.
We report four cases of mucormycosis that occurred among 711 patients who underwent BMT for thalassemia, and review 18 additional cases among BMT recipients that were reported in the English-language literature. All these patients were polytransfused and were in advanced phase of disease with severe acquired hemochromatosis. The sites of infection were sinonasal, rhinocerebral-pulmonary, pulmonary and pulmonary-central nervous system. Mucormycosis was the primary cause of death in three of four patients. Two infections were detected within the first 100 days after BMT. Only one of the four patients had partial resolution of sinonasal mucormycosis following aggressive antifungal therapy combined with hyperbaric oxygen treatment.
我们报告了711例接受骨髓移植治疗地中海贫血患者中发生的4例毛霉菌病病例，并回顾了英文文献中报道的另外18例骨髓移植受者中的病例。所有这些患者均多次输血，处于疾病晚期，伴有严重的获得性血色素沉着症。感染部位为鼻窦、鼻脑-肺、肺和肺-中枢神经系统。毛霉菌病是4例患者中3例的主要死亡原因。2例感染在骨髓移植后的前100天内被检测到。4例患者中只有1例在积极的抗真菌治疗联合高压氧治疗后鼻窦毛霉菌病得到部分缓解。
