脂多糖对大鼠脑和肾上腺中ICE mRNA及酶活性的区域特异性诱导作用。
Regionally specific induction of ICE mRNA and enzyme activity in the rat brain and adrenal gland by LPS.
作者信息
Tingsborg S, Zetterström M, Alheim K, Hasanvan H, Schultzberg M, Bartfai T
机构信息
Department of Neurochemistry and Neurotaxicology, Stockholm University, Sweden.
出版信息
Brain Res. 1996 Mar 11;712(1):153-8. doi: 10.1016/0006-8993(95)01525-6.
Pro interleukin-1 beta converting enzyme (ICE) activity in the pituitary was found to be significantly increased 4 h after intraperitoneal injection of E. coli lipopolysaccharides, when distribution and inducibility of the enzyme was studied in the adult rat brain and the adrenal gland, using an artificial fluorescence peptide substrate. The same lipopolysaccharide treatment induced ICE mRNA levels in the pituitary, adrenal gland and hypothalamus as studied by reverse transcript-polymerase chain reaction.
当利用人工荧光肽底物在成年大鼠脑和肾上腺中研究白细胞介素-1β转换酶（ICE）前体的分布和诱导性时，发现腹腔注射大肠杆菌脂多糖4小时后，垂体中的ICE前体活性显著增加。通过逆转录-聚合酶链反应研究发现，相同的脂多糖处理可诱导垂体、肾上腺和下丘脑的ICE信使核糖核酸水平升高。
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