Hammerberg B, Musoke A J, Williams J F
J Parasitol. 1977 Apr;63(2):327-31.
Factors present in hydatid cyst fluid of Echinococcus granulosus were found to interact with complement from several species. This nonimmunologic fixation resulted in the depletion of hemolytically active complement from fresh guinea pig serum, the conversion of human C3 to an electrophoretically faster species and the genration of smooth muscle contracting substances, analogous to anaphylatoxins, in normal rat serum in vitro. Vascular permeability changes were produced in vivo in rats and humans after intradermal inoculation of complement interacting fractions of hydatid fluid. It is suggested that these factors may contribute to the pathogenesis of the shock syndrome which follows intravenous administration of hydatid fluid in normal animals, and to the nonspecificity of immunodiagnostic skin tests for hydatid infection in man and animals.
已发现细粒棘球绦虫包虫囊肿液中的因子可与多种物种的补体相互作用。这种非免疫固定导致新鲜豚鼠血清中具有溶血活性的补体耗竭，人C3转化为电泳速度更快的物种，并在体外正常大鼠血清中产生类似于过敏毒素的平滑肌收缩物质。皮内接种包虫液的补体相互作用组分后，大鼠和人类在体内出现血管通透性变化。有人提出，这些因子可能促成正常动物静脉注射包虫液后发生的休克综合征的发病机制，以及人和动物包虫感染免疫诊断皮肤试验的非特异性。
