Goto M
Jpn Circ J. 1977 Mar;41(3):299-308. doi: 10.1253/jcj.41.299.
The experiments were performed on dogs to confirm the hypothesis that the left atrium plays an important role in raising the pulmonary arterial pressure through the autonomic nervous system. In Experiment I, the left auricular resection of dogs resulted in elevated pulmonary arterial pressure. In Experiment 2, 6% Dextran infusion was performed on four groups of dogs: (1) intact dogs (2) dogs with the left auricular resection (3) with the cardiac denervation (4) with both the left auricular resection and the cardiac denervation. The pulmonary arterial resistance increased after the infusion in the dogs with simple left auricular resection, but was relatively unchanged in all others. The result shows that cardiac denervation prevents the increase of the pulmonary arterial resistance due to the left auricular resection. From this we can conclude that the left auricular resection causes an increase in the pulmonary arterial resistance through the autonomic nervous system.
为了证实左心房通过自主神经系统在升高肺动脉压方面起重要作用这一假说，在狗身上进行了实验。在实验一中，切除狗的左心耳导致肺动脉压升高。在实验二中，对四组狗进行了6%右旋糖酐输注：(1) 完整的狗；(2) 切除左心耳的狗；(3) 心脏去神经支配的狗；(4) 既切除左心耳又进行心脏去神经支配的狗。单纯切除左心耳的狗在输注后肺动脉阻力增加，但其他所有组相对未变。结果表明，心脏去神经支配可防止因切除左心耳而导致的肺动脉阻力增加。由此我们可以得出结论，切除左心耳通过自主神经系统导致肺动脉阻力增加。
