Hori M, Fukui S, Nishimoto Y, Inoue M, Abe H
Jpn Heart J. 1977 Mar;18(2):202-13. doi: 10.1536/ihj.18.202.
A new method was developed to estimate the peak serum lactic dehydrogenase (LDH) value in patients with acute myocardial infarction from a single determination of serum LDH activity in the post-peak period (3rd to 5th day after the onset of infarction) using nomogram method based on the monoexponential decay of serum LDH with a decay constant of 0.012 hours-1. To develop this nomogram, the serial changes in serum LDH activities were studied in 30 patients with acute myocardial infarction admitted to the coronary care unit within the pre-peak period. The mean errors in estimation from data of the 3rd, 4th, or 5th day after the onset were acceptably small, 10.5 +/- 1.9%, 14.5 +/- 2.8%, and 15.9 +/- 3.3%, respectively. Furthermore, a correction formula was obtained to improve the accuracy of estimation, since the peak values were underestimated in patients with actual peak values less than 300 units and overestimated in the case of more than 500 units. Estimation in 9 patients of an external sample group confirmed that this nomogram is useful clinically with mean errors of less than 25%.
开发了一种新方法，用于根据梗死高峰后期（梗死发作后第3至5天）血清乳酸脱氢酶（LDH）活性的单次测定，使用基于血清LDH单指数衰减（衰减常数为0.012小时-1）的列线图方法来估计急性心肌梗死患者的血清LDH峰值。为了绘制此列线图，研究了30例在高峰前期入住冠心病监护病房的急性心肌梗死患者血清LDH活性的系列变化。从发病后第3、4或5天的数据进行估计时的平均误差较小，分别为10.5±1.9%、14.5±2.8%和15.9±3.3%，可以接受。此外，还获得了一个校正公式以提高估计的准确性，因为实际峰值小于300单位的患者峰值被低估，而大于500单位的患者峰值被高估。对一个外部样本组的9例患者进行的估计证实，此列线图在临床上有用，平均误差小于25%。
