Jesudason M V, Malathy B, John T J
Department of Microbiology, Christian Medical College & Hospital, Vellore.
Indian J Med Res. 1996 May;103:247-9.
The minimum inhibitory concentration (MIC) of ciprofloxacin has been determined in 193 strains of S. typhi isolated during January and July each year from March 1991 to July 1995. While all strains remained within established range of susceptibility, a clear trend of increase of MIC values with time was observed. During the first four study periods, all strains had MIC values below 0.031 microgram/ml; during the fifth and sixth, 3 strains had a higher value namely 0.125 microgram/ml. During the last four, 14 strains showed MIC values of 0.25 microgram/ml. Thus an increase in MIC of ciprofloxacin to S. typhi has been observed over the years.
对1991年3月至1995年7月期间每年1月和7月分离出的193株伤寒沙门氏菌测定了环丙沙星的最低抑菌浓度（MIC）。虽然所有菌株仍在既定的敏感范围内，但观察到MIC值随时间有明显的上升趋势。在最初四个研究阶段，所有菌株的MIC值均低于0.031微克/毫升；在第五和第六阶段，有3株菌株的值较高，即0.125微克/毫升。在最后四个阶段，有14株菌株的MIC值为0.25微克/毫升。因此，多年来已观察到环丙沙星对伤寒沙门氏菌的MIC有所增加。
