Nishi M, Miyake H, Takeda T, Shimada M
Department of Public Health, Sapporo Medical College, Japan.
Int J Cancer. 1996 Jul 29;67(3):323-6. doi: 10.1002/(SICI)1097-0215(19960729)67:3<323::AID-IJC3>3.0.CO;2-T.
The population-based epidemiological indices (crude incidence, survival rate, mortality, etc.) of childhood leukemia (0-14 years of age) from 1969 to 1993 in Hokkaido Prefecture, Japan, were calculated, using data obtained from the Registry of Childhood Malignancies in Hokkaido Prefecture. A total of 1,084 cases of leukemia were diagnosed in the 1969-93 period. The annual incidence of all types of leukemia from 1984 to 1993 was about 4 per 100,000 children aged 0-14 years, with the incidence of ANLL decreasing slightly and that of ALL increasing. The ratio of ALL/ANLL could similarly be seen to be increasing in all age groups. Out of a cohort of 100,000 live births, about 65 children developed leukemia by 14 years of age, and in this longitudinal observation the ratio of ALL/ANLL was increasing. The incidence of ALL and ANLL and the ratio of ALL/ANLL in Japanese children are approaching those of Caucasians. Approximately 80% of the ALL cases were of the LI type (FAB classification), and about 65% of these could be immunologically classified as "common" ALL. The 5-year survival rate of T- and B-cell ALL cases was 50% or less, while that of "common" ALL cases was about 80%.
利用从北海道儿童恶性肿瘤登记处获得的数据，计算了1969年至1993年日本北海道地区儿童白血病（0至14岁）基于人群的流行病学指标（粗发病率、生存率、死亡率等）。在1969 - 93年期间共诊断出1084例白血病病例。1984年至1993年所有类型白血病的年发病率约为每10万名0至14岁儿童中有4例，其中急性非淋巴细胞白血病（ANLL）的发病率略有下降，而急性淋巴细胞白血病（ALL）的发病率上升。ALL/ANLL的比例在所有年龄组中同样呈上升趋势。在10万例活产队列中，约65名儿童在14岁前患白血病，在这一纵向观察中ALL/ANLL的比例在上升。日本儿童中ALL和ANLL的发病率以及ALL/ANLL的比例正接近白种人。大约80%的ALL病例为L1型（FAB分类），其中约65%在免疫方面可归类为“普通”ALL。T细胞和B细胞ALL病例的5年生存率为50%或更低，而“普通”ALL病例的5年生存率约为80%。
