Imanishi K, Inada K, Akatsuka H, Gu Y, Igarashi H, Uchiyama T
Department of Microbiology and Immunology, Tokyo Women's Medical College, Japan.
Int J Immunopharmacol. 1995 Oct;17(10):841-8. doi: 10.1016/0192-0561(95)00074-c.
Tumor necrosis factor (TNF) production from T-cells stimulated with superantigenic exotoxins, staphylococcal enterotoxin B and streptococcal pyrogenic exotoxin A was investigated in the presence of cells bearing distinct isotypes of HLA class II molecules. The main T-cell subset for TNF production was investigated in parallel. Similarly high levels of TNF production were induced upon stimulation with the toxins in the presence of DR+ or DQ+ cells, but only marginal levels of TNF production were induced in the presence of DP+ cells. Although both CD4+ T-cells and CD8+ T-cells produced TNF-alpha and TNF-beta in response to toxin stimulation in the presence of HLA class II+ cells, the former T-cell subset was the major source of producers of TNF-alpha and TNF-beta.
