Ortonne J P, Schmitt D, Alario A, Thivolet J
Acta Derm Venereol. 1979;59(3):211-8.
Six patients (5 with mycosis fungoides and 1 with lichen planus) treated with PUVA, were subjected to biopsy of lesional skin before and during oral photochemotherapy. Ultrastructurally, a reduction in the density of cellular infiltrate was observed in the superficial dermis. In the same areas, necrotic cellular changes were observed. PUVA therapy exercises its beneficial effect by direct destruction of these cells.
6例接受补骨脂素加长波紫外线（PUVA）治疗的患者（5例蕈样肉芽肿患者和1例扁平苔藓患者）在口服光化学疗法之前和期间接受了皮损活检。超微结构观察发现，浅表真皮层细胞浸润密度降低。在相同区域，观察到细胞坏死性改变。PUVA疗法通过直接破坏这些细胞发挥其有益作用。
