Ortonne J P, Thivolet J, Sannwald C
Br J Dermatol. 1978 Jul;99(1):77-88. doi: 10.1111/j.1365-2133.1978.tb01964.x.
Seven patients with diffuse lichen planus were treated with oral photochemotherapy. Remission was effected in 6 cases. The only failure may be attributable to a low UVA dose. Histological examination after treatment showed disappearance of the superficial dermal lymphocytic infiltrate. Ultrastructural study revealed nuclear alterations of keratinocytes and nuclear and cytoplasmic changes in superficial dermal cells. Various theories concerning the mode of action of photochemotherapy in lichen planus are discussed in the light of these observations.
7例泛发性扁平苔藓患者接受了口服光化学疗法治疗。6例患者病情缓解。唯一的治疗失败可能归因于紫外线A（UVA）剂量较低。治疗后的组织学检查显示真皮浅层淋巴细胞浸润消失。超微结构研究揭示了角质形成细胞的核改变以及真皮浅层细胞的核和胞质变化。根据这些观察结果，讨论了关于光化学疗法治疗扁平苔藓作用方式的各种理论。
