Kato N, Matsue K, Sotodate A, Tomita Y
Department of Dermatology, National Sapporo Hospital, Japan.
J Dermatol. 1996 Jun;23(6):408-14. doi: 10.1111/j.1346-8138.1996.tb04043.x.
We report a 68-year-old Japanese man with invasive extramammary Paget's disease (EPD) which started in the left inguinal area and enlarged to include the scrotal skin, penis, and pubic area, resulting in lymph edema of the entire left leg. Histopathological examination of one nodule revealed an intraepidermal and intradermal arrangement of solid tumor cells with characteristic pale cytoplasm. The tumor was found to have disseminated to regional and systemic lymph nodes, lungs, bones, and the left adrenal gland. In addition, the patient had a metastatic cutaneous nodule on the scalp. Histology of the skin metastasis showed that the proliferation of Paget cells was confined to the dermis. This type of metastatic spread of EPD is very rare; only two other apparent cases in Japan have been reported.
我们报告了一名68岁的日本男性，患有侵袭性乳腺外佩吉特病（EPD），该病始于左腹股沟区，随后扩大至阴囊皮肤、阴茎和耻骨区域，导致整条左腿出现淋巴水肿。对一个结节进行组织病理学检查发现，实体瘤细胞呈表皮内和真皮内排列，细胞质具有特征性的淡染。发现肿瘤已扩散至区域和全身淋巴结、肺、骨骼及左肾上腺。此外，患者头皮上有一个转移性皮肤结节。皮肤转移灶的组织学检查显示，佩吉特细胞的增殖局限于真皮。EPD的这种转移扩散非常罕见；日本仅另有两例明显的病例报告。
