Mellissinos K G, Vlassopoulos K S, Drivas G J, Tsoukandas A G
Nephron. 1977;18(3):156-61. doi: 10.1159/000180809.
The G-6-PD activity of erythrocytes was studied in 75 patients with chronic renal failure and 74 normal subjects. The mean value of G-6-PD was higher in the chronic renal failure group and the difference was highly significant. During haemodialysis the G-6-PD activity did not return to normal but was further elevated, though the increase was not statistically significant. A highly significant negative correlation was found between red cell G-6-PD and haematocrit. After separation of the red cells according to age by centrifugation, G-6-PD was highest in the top (young cells) and lowest in the bottom (old) cells, both in normals and uraemic patients. The enzyme activity was higher at all levels in the uraemic subjects, significantly in the top and middle layers. Although our findings may be due to an increased proportion of young erythrocytes in uraemia there are objections to this explanation; the alternative possibility of a life-long metabolic abnormality in uraemic red cells deserves careful consideration.
对75例慢性肾衰竭患者和74名正常受试者的红细胞葡萄糖-6-磷酸脱氢酶（G-6-PD）活性进行了研究。慢性肾衰竭组的G-6-PD平均值较高，差异具有高度显著性。血液透析期间，G-6-PD活性未恢复正常，而是进一步升高，尽管升高幅度无统计学意义。发现红细胞G-6-PD与血细胞比容之间存在高度显著的负相关。通过离心按年龄分离红细胞后，正常人和尿毒症患者中，顶层（年轻细胞）的G-6-PD最高，底层（年老细胞）的最低。尿毒症患者各层的酶活性均较高，顶层和中层显著升高。虽然我们的发现可能是由于尿毒症患者中年轻红细胞比例增加，但对此解释存在异议；尿毒症红细胞终生代谢异常的另一种可能性值得仔细考虑。
