Vermersch A I, Müri R M, Rivaud S, Vidailhet M, Gaymard B, Agid Y, Pierrot-Deseilligny C
INSERM 289 Hôpital de la Salpêtrière, Paris, France.
J Neurol Neurosurg Psychiatry. 1996 Feb;60(2):179-84. doi: 10.1136/jnnp.60.2.179.
To determine the roles of the putamen and pallidum in ocular motor control.
Eye movements were recorded electro-oculographically in nine patients with bilateral focal lesions affecting the lentiform nucleus, and in 12 age matched control subjects. Reflexive visually guided saccades (gap task), antisaccades, memorised sequences of saccades, memory guided saccades (with visual input only, and with both visual and vestibular inputs), and predictive saccades (with and without gap) were studied.
Latency and accuracy of visually guided saccades were normal. The percentage of errors in the antisaccade task and latency of correct antisaccades did not differ significantly from the results of controls. The percentage of errors in saccade sequences was significantly increased. Accuracy of the two types of memory guided saccades was impaired bilaterally. The percentage of predictive saccades was significantly decreased when a gap existed, but unchanged without a gap, compared with controls. Therefore, saccades made immediately in response to an external target (reflexive visually guided saccades and antisaccades) were performed without difficulty, whereas those requiring an internal representation of such a target (such as memory guided saccades, predictive saccades, and saccade sequences) were performed with significant disturbances.
The lentiform nucleus influences the cortical areas involved in the control of saccades when the experimental paradigm requires the use of an internal representation of the target for correct planning and execution of the ensuing saccade.
确定壳核和苍白球在眼球运动控制中的作用。
对9例双侧累及豆状核的局灶性病变患者和12名年龄匹配的对照受试者进行眼电图记录眼动情况。研究了反射性视觉引导扫视（间隙任务）、反扫视、记忆性扫视序列、记忆引导扫视（仅视觉输入以及视觉和前庭输入均有）以及预测性扫视（有间隙和无间隙）。
视觉引导扫视的潜伏期和准确性正常。反扫视任务中的错误百分比和正确反扫视的潜伏期与对照组结果无显著差异。扫视序列中的错误百分比显著增加。两种类型的记忆引导扫视的准确性双侧受损。与对照组相比，存在间隙时预测性扫视的百分比显著降低，但无间隙时无变化。因此，对外部目标立即做出的扫视（反射性视觉引导扫视和反扫视）执行起来没有困难，而那些需要对这样一个目标进行内部表征的扫视（如记忆引导扫视、预测性扫视和扫视序列）执行时存在明显干扰。
当实验范式要求使用目标的内部表征来正确规划和执行随后的扫视时，豆状核会影响参与扫视控制的皮质区域。
