Foster J C, Smith H L
College of Nursing, University of Utah, Salt Lake City 84112, USA.
J Nurse Midwifery. 1996 May-Jun;41(3):211-7. doi: 10.1016/0091-2182(96)00013-4.
A prospective, randomized clinical trial was conducted to study the safety and efficacy of the Cytobrush for Papanicolaou smear screens in 252 pregnant women. Two groups-Ayre spatula plus Cytobrush and Ayre spatula plus cotton swab-were compared. There was a higher incidence of spotting with each of the three devices as compared with studies of nonpregnant women. The highest incidence of spotting at time of exam occurred with the Cytobrush; however, this spotting was not clinically significant. Eleven first-trimester women experienced a pregnancy loss; five of these losses were due to a hydatidiform mole or missed abortion that occurred before the exam. Six women (2%) aborted spontaneously compared with a 10% incidence reported in the literature. It was concluded that all three devices are safe for use in pregnancy. In addition, the most adequate screen for retrieval of squamous epithelial cells was found to be the Ayre spatula, while the Cytobrush proved most effective for retrieval of endocervical epithelial cells.
开展了一项前瞻性随机临床试验，以研究Cytobrush在252名孕妇巴氏涂片筛查中的安全性和有效性。比较了两组——艾yre刮板加Cytobrush和艾yre刮板加棉拭子。与非孕妇研究相比，三种器械中每种器械出现点滴出血的发生率都更高。检查时点滴出血发生率最高的是Cytobrush；然而，这种点滴出血在临床上并无显著意义。11名孕早期妇女发生了妊娠丢失；其中5例丢失是由于检查前发生的葡萄胎或稽留流产。6名妇女（2%）自然流产，而文献报道的发生率为10%。得出的结论是，所有三种器械在孕期使用都是安全的。此外，发现艾yre刮板最适合用于获取鳞状上皮细胞，而Cytobrush被证明在获取宫颈管上皮细胞方面最有效。
