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卵胞浆内单精子注射:一种治疗严重少精子症的方法。

Intracytoplasmic sperm injection: a treatment for extreme oligospermia.

作者信息

Gil-Salom M, Minguez Y, Rubio C, Ruiz A, Remohi J, Pellicer A

机构信息

Instituto Valenciano de Infertilidad, University of Valencia Medical School, Spain.

出版信息

J Urol. 1996 Sep;156(3):1001-4. doi: 10.1016/s0022-5347(01)65685-4.

DOI:10.1016/s0022-5347(01)65685-4
PMID:8709295
Abstract

PURPOSE

We evaluated the efficacy of intracytoplasmic sperm injection in patients with extreme oligospermia.

MATERIALS AND METHODS

A total of 67 intracytoplasmic sperm injection cycles was attempted in 58 infertile couples in which the husbands had extreme oligospermia (less than 100,000 spermatozoa per ml. ejaculate).

RESULTS

Fertilization was achieved in 65 of 67 cycles. Mean fertilization rate per cycle was 66.4%. A total of 18 clinical pregnancies was obtained, for a pregnancy rate of 26.8% per started cycle. There were 4 miscarriages and 8 live births from 5 deliveries. Nine pregnancies are ongoing.

CONCLUSIONS

Intracytoplasmic sperm injection in patients with extreme oligospermia is associated with high fertilization rates and offers the chance of pregnancy to these otherwise intractably infertile couples.

摘要

目的

我们评估了卵胞浆内单精子注射对严重少精子症患者的疗效。

材料与方法

对58对不育夫妇共尝试了67个卵胞浆内单精子注射周期,这些夫妇的丈夫患有严重少精子症(每毫升精液中精子少于100,000个)。

结果

67个周期中有65个实现了受精。每个周期的平均受精率为66.4%。共获得18例临床妊娠,起始周期的妊娠率为26.8%。5次分娩中有4例流产,8例活产。9例妊娠仍在继续。

结论

严重少精子症患者进行卵胞浆内单精子注射受精率高,为这些原本难以治疗的不育夫妇提供了妊娠机会。

相似文献

1
Intracytoplasmic sperm injection: a treatment for extreme oligospermia.卵胞浆内单精子注射:一种治疗严重少精子症的方法。
J Urol. 1996 Sep;156(3):1001-4. doi: 10.1016/s0022-5347(01)65685-4.
2
Testicular sperm extraction and intracytoplasmic sperm injection: a chance of fertility in nonobstructive azoospermia.睾丸精子提取术及卵胞浆内单精子注射术:非梗阻性无精子症患者的生育希望
J Urol. 1998 Dec;160(6 Pt 1):2063-7.
3
Intracytoplasmic testicular sperm injection: an effective treatment for otherwise intractable obstructive azoospermia.卵胞浆内单精子注射:治疗其他方法难以治愈的梗阻性无精子症的有效方法。
J Urol. 1995 Dec;154(6):2074-7. doi: 10.1016/s0022-5347(01)66698-9.
4
Testicular sperm extraction with intracytoplasmic sperm injection for nonobstructive azoospermia.睾丸精子提取联合卵胞浆内单精子注射治疗非梗阻性无精子症
Urology. 1997 Mar;49(3):435-40. doi: 10.1016/S0090-4295(97)00032-0.
5
In vitro fertilization treatment for severe male factor: a comparative study of intracytoplasmic sperm injection with testicular sperm extraction and with spermatozoa from ejaculate.重度男性因素的体外受精治疗:睾丸精子提取的卵胞浆内单精子注射与射精精子的比较研究
J Assist Reprod Genet. 1998 Jul;15(6):386-9. doi: 10.1023/a:1022537117578.
6
Factors of importance for the establishment of a successful program of intracytoplasmic sperm injection treatment for male infertility.对于建立成功的男性不育症胞浆内单精子注射治疗方案具有重要意义的因素。
Fertil Steril. 1995 Apr;63(4):828-37. doi: 10.1016/s0015-0282(16)57489-5.
7
High implantation and pregnancy rates with testicular sperm extraction and intracytoplasmic sperm injection in obstructive and non-obstructive azoospermia.在梗阻性和非梗阻性无精子症患者中,睾丸精子提取术联合卵胞浆内单精子注射术具有较高的着床率和妊娠率。
Hum Reprod. 1996 Mar;11(3):673-6. doi: 10.1093/humrep/11.3.673.
8
Pregnancies achieved with testicular and ejaculated spermatozoa in combination with intracytoplasmic sperm injection in men with totally or initially immotile spermatozoa in the ejaculate.对于射精时精子完全或最初无活动力的男性,通过睾丸精子和射出精子联合卵胞浆内单精子注射实现的妊娠。
Hum Reprod. 1996 Jun;11(6):1343-6. doi: 10.1093/oxfordjournals.humrep.a019384.
9
Outcome of intracytoplasmic sperm injection with testicular spermatozoa in obstructive and non-obstructive azoospermia.
Hum Reprod. 1996 May;11(5):1015-8. doi: 10.1093/oxfordjournals.humrep.a019288.
10
Effect of sperm DNA fragmentation on clinical outcomes for Chinese couples undergoing in vitro fertilization or intracytoplasmic sperm injection.精子DNA碎片化对接受体外受精或卵胞浆内单精子注射的中国夫妇临床结局的影响。
J Int Med Res. 2016 Dec;44(6):1283-1291. doi: 10.1177/0300060516664240. Epub 2016 Nov 11.

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