Stark C, Kahrmann B, Walzel E
Department of Nutritional Toxicology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
Lab Anim. 1996 Jan;30(1):35-41. doi: 10.1258/002367796780744965.
Development and morphology of the epiphyses of the long bones were investigated in 93 adult rats of 7 different strains (BDIX/Han, BDE/Han, BN/Han, DA/Han, LEW/Han, AVN/IpcV/Wistar/Rehbrücke, Shoe: WIST) from the age of 14 weeks up to the age of 78 weeks. Strain-related differences were found in the development of the secondary centre of ossification, which was retarded in the BDIX/Han rats. Furthermore, closure of the growth plate started earlier in the BDIX/Han rats. In addition various regressive changes were detected in the growth plates of long bones of all rats, but not of the ribs. The frequency and extent of these changes varied between individuals and strains. Degeneration of the matrix and necrosis were already observed at 14 weeks of age.
对93只7种不同品系（BDIX/Han、BDE/Han、BN/Han、DA/Han、LEW/Han、AVN/IpcV/Wistar/Rehbrücke、鞋号：WIST）的成年大鼠进行了研究，观察其从14周到78周龄长骨骨骺的发育和形态。在次级骨化中心的发育中发现了品系相关差异，BDIX/Han大鼠的发育延迟。此外，BDIX/Han大鼠生长板的闭合开始得更早。此外，在所有大鼠长骨的生长板中均检测到各种退行性变化，但肋骨未出现。这些变化的频率和程度因个体和品系而异。在14周龄时就已观察到基质退变和坏死。
