England J D, Happel L T, Kline D G, Gamboni F, Thouron C L, Liu Z P, Levinson S R
Department of Neurology, Louisiana State University School of Medicine, New Orleans, 70112-2822, USA.
Neurology. 1996 Jul;47(1):272-6. doi: 10.1212/wnl.47.1.272.
Painful neuromas from 16 patients were examined using site-specific antisodium channel antibodies employed in immunocytochemical and radioimmunoassay methods. Normal sural nerves from six of these patients served as controls. Immunocytochemistry showed abnormal segmental accumulation of sodium channels within many axons in the neuromas. Dens immunolocalization was especially apparent within the axonal tips. Radioimmunoassay confirmed a significantly greater density of sodium channels in the neuromas as compared with the sural nerves. Thus, sodium channel accumulate abnormally within the axons of neuromas in humans. This alteration of the sodium channels may underlie the generation of axonal hyperexcitability and the resulting abnormal sensory phenomena (pain and paresthesias), which frequently occur after peripheral nerve injury.
使用位点特异性抗钠通道抗体，通过免疫细胞化学和放射免疫测定方法对16例患者的疼痛性神经瘤进行了检查。其中6例患者的正常腓肠神经用作对照。免疫细胞化学显示神经瘤中许多轴突内钠通道有异常节段性积聚。密集免疫定位在轴突末端尤为明显。放射免疫测定证实，与腓肠神经相比，神经瘤中钠通道密度明显更高。因此，钠通道在人类神经瘤的轴突内异常积聚。钠通道的这种改变可能是轴突兴奋性过高以及由此产生的异常感觉现象（疼痛和感觉异常）的基础，这些现象常在周围神经损伤后频繁出现。
