Halsey J H, Capra N F, McFarland R S
Stroke. 1977 May-Jun;8(3):351-7. doi: 10.1161/01.str.8.3.351.
The extreme diffusibility of hydrogen, compared with xenon or krypton, may create serious artifacts when it is used to measure local blood flow with a tissue electrode. The errors are greatest when hydrogen is given by intra-arterial slug injection, and when the electrode is within 2mm of another tissue compartment, CSF, or air. These all appear to be a consequence of intercompartmental diffusion which can occur at rates of the same order of magnitude as clearance from the tissue by blood flow. No matter how small the electrode, the ultimate spatial resolution of the method appears to be about 2mm unless quantitative account is taken of diffusion. An important precaution in use of the method is to obtain homogeneous tissue saturation by prolonged inhalation administration.
与氙或氪相比，氢气的极高扩散性在使用组织电极测量局部血流时可能会产生严重伪影。当通过动脉内团注给予氢气，且电极距离另一个组织腔室、脑脊液或空气在2毫米以内时，误差最大。这些似乎都是隔室间扩散的结果，其发生速率与血流从组织中清除的速率处于同一数量级。无论电极有多小，除非对扩散进行定量考虑，否则该方法的最终空间分辨率似乎约为2毫米。使用该方法的一个重要预防措施是通过长时间吸入给药使组织达到均匀饱和。
