Jarmoliński T, Zachwieja J, Bortkiewicz E, Stachowski J, Maciejewski J
II Klinika Chorób Dzieci Instytutu Pediatrii Akademii Medycznej w Poznaniu.
Pediatr Pol. 1996 May;71(5):437-41.
Eight children with thrombo-embolic disease in the course of nephrotic syndrome were treated at II Clinic of Children's Diseases (Institute of Pediatrics, Poznań) between 1991 and 1993. The diagnosis was established on the basis of clinical examination and noninvasive imaging techniques. Two patients had an atypical localisation of the thrombus in the left ventricle and right atrium. In laboratory tests of the coagulation system, all of the children had decreased levels of antithrombin III (AT III). All children were treated with heparin and 4 with fibrinolytic agents. AT III concentrate was administered to 3 children. Total resolution of thrombo-embolic disease was obtained in 5 patients, 3 died during treatment. Thrombo-embolic disease should be taken into account in the differential diagnosis of complications of nephrotic syndrome.
1991年至1993年间，波兹南儿科研究所儿童疾病二科收治了8名患有肾病综合征并伴有血栓栓塞性疾病的儿童。诊断基于临床检查和非侵入性成像技术。两名患者的血栓分别位于左心室和右心房，位置不典型。在凝血系统的实验室检查中，所有儿童的抗凝血酶III（AT III）水平均降低。所有儿童均接受肝素治疗，4名儿童接受了纤溶药物治疗。3名儿童接受了AT III浓缩剂治疗。5名患者的血栓栓塞性疾病完全消退，3名患者在治疗期间死亡。在肾病综合征并发症的鉴别诊断中应考虑血栓栓塞性疾病。
