Rostoker G, Gouault-Heilmann M, Lang P, Lagrue G
Pathol Biol (Paris). 1987 Feb;35(2):195-9.
Thrombo-embolic events remain one of the most serious complications in patients with nephrotic syndrome (NS). A causal relationship between coagulation abnormalities and the occurrence of thrombosis in NS has been searched. Several studies have demonstrated multiples abnormalities in the coagulation factors and platelets; however those studies did not provide adequate explanations for the thrombotic tendency of NS. This thrombotic tendency could be related to deficiency in natural coagulation inhibitors. Plasma ATIII level has been reported to be decreased both in some adults and children. Protein C is found normal or high in NS whereas protein S is increased. Nevertheless a possible decrease in functional protein S cannot be excluded.
血栓栓塞事件仍然是肾病综合征（NS）患者最严重的并发症之一。人们一直在探寻凝血异常与NS中血栓形成之间的因果关系。多项研究已证实凝血因子和血小板存在多种异常；然而，这些研究并未对NS的血栓形成倾向给出充分解释。这种血栓形成倾向可能与天然凝血抑制剂缺乏有关。据报道，一些成人和儿童的血浆抗凝血酶III（ATIII）水平均有所下降。在NS中，蛋白C水平正常或升高，而蛋白S水平升高。不过，不能排除功能性蛋白S可能降低的情况。
