Tsuneda Y, Hayakawa T, Yamamoto H, Ikemi T, Nemoto K
Department of Operative Dentistry, Nihon University School of Dentistry at Matsudo, Japan.
Oper Dent. 1995 Nov-Dec;20(6):223-9.
This study evaluated the histological pulp responses of four different adhesive resin systems placed directly on exposed pulp tissue. Gap formation between the respective resin and cavity walls was observed and correlated to the pulpal response. Occlusal cavity preparations creating mechanical pulp exposures were prepared in molars of wistar rats. Preparations were filled using one of the following resin systems: 1) Superbond C&B system, 2) Clearfil Liner Bond system, 3) Tokuso Light Bond system, and 4) Scotchbond Multi-Purpose One All system. Although there were no significant differences in the pulpal responses after 3 days, significant differences were observed after 7 days. Results showed that the Superbond C&B system induced only a slight initial reaction, while secondary dentin was observed at the 30-day postoperative evaluation period. The Clearfil Liner Bond system showed a slight initial reaction to the materials, but exhibited slight pulpal necrosis and formation of secondary dentin at the 90-day evaluation period. The Tokuso Light Bond and One All systems showed severe pulpal reactions at all evaluation periods with no formation of secondary dentin. Microleakage formation correlated with the histopathological responses. Superbond C&B exhibited no microleakage, and only slight microleakage was observed when the Clearfil Bond system was used. The Tokuso and One All systems exhibited a wide area of microleakage. Further in vivo study evaluating the clinical use of adhesive resins for pulp capping is necessary to determine which resin systems may be used for direct pulp capping without incurring severe damage to pulpal tissue.
本研究评估了直接放置于暴露牙髓组织上的四种不同粘结树脂系统的组织学牙髓反应。观察了各树脂与洞壁之间的间隙形成情况，并将其与牙髓反应相关联。在Wistar大鼠的磨牙上制备造成机械性牙髓暴露的咬合洞形。使用以下树脂系统之一进行充填：1）Superbond C&B系统；2）Clearfil Liner Bond系统；3）Tokuso Light Bond系统；4）Scotchbond Multi-Purpose One All系统。虽然3天后牙髓反应无显著差异，但7天后观察到显著差异。结果显示，Superbond C&B系统仅引起轻微的初始反应，而在术后30天评估期观察到继发性牙本质形成。Clearfil Liner Bond系统对材料表现出轻微的初始反应，但在90天评估期出现轻微牙髓坏死和继发性牙本质形成。Tokuso Light Bond系统和One All系统在所有评估期均表现出严重的牙髓反应，无继发性牙本质形成。微渗漏的形成与组织病理学反应相关。Superbond C&B系统未出现微渗漏，使用Clearfil Bond系统时仅观察到轻微微渗漏。Tokuso系统和One All系统出现大面积微渗漏。有必要进行进一步的体内研究，以评估粘结树脂用于牙髓盖髓术的临床应用，从而确定哪些树脂系统可用于直接盖髓而不引起牙髓组织的严重损伤。
