Shima K, Mushiake H, Saito N, Tanji J
Department of Physiology, Tohoku University School of Medicine, Sendai, Japan.
Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8694-8. doi: 10.1073/pnas.93.16.8694.
Two motor areas are known to exist in the medial frontal lobe of the cerebral cortex of primates, the supplementary motor area (SMA) and the presupplementary motor area (pre-SMA). We report here on an aspect of cellular activity that characterizes the pre-SMA. Monkeys were trained to perform three different movements sequentially in a temporal order. The correct order was planned on the basis of visual information before its execution. A group of pre-SMA cells (n = 64, 25%) were active during a process when monkeys were required to discard a current motor plan and develop a plan appropriate for the next orderly movements. Such activity was not common in the SMA and not found in the primary motor cortex. Our data suggest a role of pre-SMA cells in updating motor plans for subsequent temporally ordered movements.
已知在灵长类动物大脑皮层的内侧额叶存在两个运动区域，即辅助运动区（SMA）和前辅助运动区（pre-SMA）。我们在此报告前辅助运动区所具有的细胞活动特征。猴子经过训练，需按时间顺序依次执行三种不同的动作。正确顺序在执行前根据视觉信息进行规划。当猴子需要放弃当前运动计划并制定适合下一个有序动作的计划时，一组前辅助运动区细胞（n = 64，25%）会活跃起来。这种活动在辅助运动区并不常见，在初级运动皮层中也未发现。我们的数据表明，前辅助运动区细胞在为后续按时间顺序排列的动作更新运动计划中发挥作用。
