Wolgemuth D J, Rhee K, Wu S, Ravnik S E
Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Reprod Fertil Dev. 1995;7(4):669-83. doi: 10.1071/rd9950669.
Gametogenesis in both the male and female mammal represents a specialized and highly regulated series of cell cycle events, involving both mitosis and meiosis as well as subsequent differentiation. Recent advances in our understanding of the genetic control of the eukaryotic cell cycle have underscored the evolutionarily-conserved nature of these regulatory processes. However, most of the data have been obtained from yeast model systems and mammalian cell lines. Furthermore, most of the observations focus on regulation of mitotic cell cycles. In the present paper: (i) aspects of gametogenesis in mammals that represent unique cell-cycle control points are highlighted; (ii) current knowledge on the regulation of the germ cell cycle, in the context of what is known in yeast and other model eukaryotic systems, is summarized; and (iii) strategies that can be used to identify additional cell cycle regulating genes are outlined.
雄性和雌性哺乳动物的配子发生代表了一系列特殊且高度受调控的细胞周期事件，涉及有丝分裂、减数分裂以及随后的分化过程。我们对真核细胞周期遗传控制的理解取得了新进展，这凸显了这些调控过程在进化上的保守性。然而，大多数数据是通过酵母模型系统和哺乳动物细胞系获得的。此外，大多数观察结果集中在有丝分裂细胞周期的调控上。在本文中：（i）强调了哺乳动物配子发生中代表独特细胞周期控制点的方面；（ii）在酵母和其他模式真核系统已知情况的背景下，总结了关于生殖细胞周期调控的当前知识；（iii）概述了可用于鉴定其他细胞周期调控基因的策略。
