Beijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Cells. 2019 Jun 10;8(6):567. doi: 10.3390/cells8060567.
Mitosis is a highly sophisticated and well-regulated process during the development and differentiation of mammalian gametogenesis. The regulation of mitosis plays an essential role in keeping the formulation in oogenesis and gametogenesis. In the past few years, substantial research progress has been made by showing that cyclins/cyclin-dependent kinase (CDK) have roles in the regulation of meiosis. In addition, more functional signaling molecules have been discovered in mitosis. Growing evidence has also indicated that miRNAs influence cell cycling. In this review, we focus on specific genes, cyclins/Cdk, signaling pathways/molecules, and miRNAs to discuss the latest achievements in understanding their roles in mitosis during gametogenesis. Further elucidation of mitosis during gametogenesis may facilitate delineating all processes of mammalian reproduction and the development of disease treatments.
有丝分裂是哺乳动物配子发生发育和分化过程中高度复杂和精确调控的过程。有丝分裂的调控对于卵母细胞发生和配子发生的维持起着至关重要的作用。在过去的几年中，大量的研究进展表明细胞周期蛋白/细胞周期依赖性激酶（CDK）在减数分裂的调控中起作用。此外，更多功能信号分子在有丝分裂中被发现。越来越多的证据表明 miRNAs 影响细胞周期。在这篇综述中，我们专注于特定基因、细胞周期蛋白/CDK、信号通路/分子和 miRNAs，讨论在配子发生中理解它们在有丝分裂中的作用的最新成果。进一步阐明配子发生中的有丝分裂可能有助于描绘哺乳动物生殖的所有过程和疾病治疗的发展。
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