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一类用于检测罕见疾病“一般”和“聚焦”聚集性的测试。

A class of tests for detecting 'general' and 'focused' clustering of rare diseases.

作者信息

Tango T

机构信息

Department of Epidemiology, Institute of Public Health, Tokyo, Japan.

出版信息

Stat Med. 1995;14(21-22):2323-34. doi: 10.1002/sim.4780142105.

DOI:10.1002/sim.4780142105
PMID:8711272
Abstract

This paper proposes a class of tests applicable to the detection of two types of disease clustering 'focused' and 'general' clustering. The former assesses the clustering of observed cases around the fixed point and the latter does not have any prior information on the centre of clustering. The proposed test for 'general' clustering is a generalization of the index for temporal clustering proposed by Tango in that it adjusts for differences in population densities and also in population distributions among categories of the counfounders such as age and sex. Simulation study shows that the proposed 'general' test outperformed the average distance method of Whittemore et al. in most of the cluster models considered.

摘要

本文提出了一类适用于检测两种疾病聚集类型的检验方法,即“聚焦型”和“一般型”聚集。前者评估观察到的病例围绕固定点的聚集情况,而后者在聚集中心方面没有任何先验信息。所提出的“一般型”聚集检验是对Tango提出的时间聚集指数的推广,因为它对人口密度差异以及年龄和性别等混杂因素类别之间的人口分布差异进行了调整。模拟研究表明,在所考虑的大多数聚集模型中,所提出的“一般型”检验优于Whittemore等人的平均距离法。

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