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里海沿岸的基因与人群:伊朗北部的一项群体遗传学研究。

Genes and people in the Caspian Littoral: a population genetic study in Northern Iran.

作者信息

Kirk R L, Keats B, Blake N M, McDermid E M, Ala F, Karimi M, Nickbin B, Shabazi H, Kmet J

出版信息

Am J Phys Anthropol. 1977 May;46(3):377-90. doi: 10.1002/ajpa.1330460302.

DOI:10.1002/ajpa.1330460302
PMID:871149
Abstract

Data for the distribution of alleles controlling two blood group systems and secretor status, for hemoglobin types, five serum protein groups and 15 red cell enzyme systems has been obtained. Eleven of the systems showed polymorphic variation and these systems have been used to calculate genetic distances using Morton's Kinship measure. No systematic relationship between genetic distance and geographic location of linguistic affiliation is apparent. There is, however, an apparent cline of decreasing frequency of PGDc from east to west and also significant differences in the frequency of G6PD deficiency corresponding to variation in the ecology of the region. Genetic distance comparisons with other selected populations reveal that the Turkic and Turkoman speaking peoples in the Caspian area cluster with the Kurds, Greeks and Iranis. The Persian speakers are genetically remote from these populations; they are, however, close to the Parsis who migrated from Iran to India at the end of the Seventh Century A.D. Several unusual genetic variants were detected, including a novel MDH phenotype, a superoxide dismutase phenotype identical with the Scandinavian type, and rare forms of LDH, PGM locus 2, ceruloplasmin, diaphorase, peptidases and PHI.

摘要

已获得控制两个血型系统、分泌状态、血红蛋白类型、五种血清蛋白组和15种红细胞酶系统的等位基因分布数据。其中11个系统表现出多态性变异,这些系统已被用于使用莫顿亲属关系度量来计算遗传距离。遗传距离与语言归属的地理位置之间没有明显的系统关系。然而,PGDc的频率从东到西明显呈下降趋势,并且G6PD缺乏症的频率也存在显著差异,这与该地区的生态变化相对应。与其他选定人群的遗传距离比较表明,里海地区说突厥语和土库曼语的民族与库尔德人、希腊人和伊朗人聚集在一起。说波斯语的人与这些人群在遗传上相距较远;然而,他们与公元7世纪末从伊朗迁移到印度的帕西人关系密切。检测到几种不寻常的遗传变异,包括一种新的MDH表型、一种与斯堪的纳维亚类型相同的超氧化物歧化酶表型,以及罕见形式的LDH、PGM位点2、铜蓝蛋白、黄递酶、肽酶和PHI。

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Reduction of bias in estimating the frequency of recessive genes.减少隐性基因频率估计中的偏差。
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Am J Hum Genet. 1986 Jan;38(1):84-98.
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Oesophageal cancer in Greenland: selected epidemiological and clinical aspects.格陵兰的食管癌:选定的流行病学和临床方面
J Cancer Res Clin Oncol. 1979 May 14;94(1):69-80. doi: 10.1007/BF00405351.
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Rare variants, private polymorphisms, and locus heterozygosity in Amerindian populations.美洲印第安人群体中的罕见变异、私有多态性和基因座杂合性。
Am J Hum Genet. 1978 Sep;30(5):465-90.