Cogliano V J, Hiatt G F, Den A
United States Environmental Protection Agency, National Center for Environmental Assessment, Washington, DC 20460, USA.
Toxicology. 1996 Jul 17;111(1-3):21-8. doi: 10.1016/0300-483x(96)03390-2.
Complementary sources of information are analyzed to characterize the early-life cancer risk from inhaling vinyl chloride. A study of partial-lifetime exposures suggests that the lifetime cancer risk depends on age at exposure, with higher lifetime risks attributable to exposures at younger ages. Studies of newborn animal exposures further demonstrate that a brief exposure in newborns can, by the end of life, induce a higher incidence of tumors compared to long-term exposure occurring later in life, including tumor types not induced by exposure later in life. An empirical, quantitative approach is used to model early-life sensitivity to inhaled vinyl chloride, supplementing conventional approaches for estimating the increased cancer risk from lifetime exposure. A single estimate is not presumed to apply to the entire population; instead, the new approach makes distinctions about the cancer risks for different population segments. This assessment shows one way such information might be analyzed, presented, and used to assess actual exposure situations.
分析补充信息来源，以描述吸入氯乙烯对生命早期癌症风险的影响。一项关于部分生命周期暴露的研究表明，终身癌症风险取决于暴露时的年龄，年轻时暴露导致的终身风险更高。对新生动物暴露的研究进一步表明，与生命后期的长期暴露相比，新生儿期的短暂暴露在生命结束时可诱发更高的肿瘤发生率，包括生命后期暴露不会诱发的肿瘤类型。采用实证定量方法对生命早期对吸入氯乙烯的敏感性进行建模，补充了估计终身暴露导致癌症风险增加的传统方法。并不假定单一估计适用于整个人口；相反，新方法区分了不同人群的癌症风险。本评估展示了分析、呈现此类信息并将其用于评估实际暴露情况的一种方式。
