Rice J M
Environ Health Perspect. 1981 Oct;41:179-88. doi: 10.1289/ehp.8141179.
The carcinogenicity of vinyl chloride for experimental animals when administered transplacentally is reviewed in comparison with known transplacental carcinogens, including those that, like vinyl chloride, are dependent on enzyme-mediated metabolic conversion to a reactive intermediate in maternal or fetal tissues. Vinyl chloride is converted by mixed-function oxidases to the reactive metabolite chlorooxirane, the carcinogenicity of which is also reviewed. Vinyl chloride is unequivocally a transplacental carcinogen for the rat. No evidence exists, however, to support the hypothesis that exposure of male rats to vinyl chloride or any other carcinogen confers an increased risk of tumor development on their progeny. Many structural analogs of vinyl chloride, i.e., substituted ethylenes, are also carcinogenic for adult animals, and can with confidence likewise be predicted to be effective transplacental carcinogens.
本文将氯乙烯经胎盘给药对实验动物的致癌性与已知的经胎盘致癌物进行了比较，这些致癌物包括像氯乙烯一样依赖酶介导的代谢转化在母体或胎儿组织中生成反应性中间体的物质。氯乙烯通过混合功能氧化酶转化为反应性代谢物氯环氧乙烷，本文也对其致癌性进行了综述。氯乙烯无疑是大鼠的经胎盘致癌物。然而，没有证据支持雄性大鼠接触氯乙烯或任何其他致癌物会使其后代患肿瘤的风险增加这一假说。许多氯乙烯的结构类似物，即取代乙烯，对成年动物也具有致癌性，同样可以肯定地预测它们是有效的经胎盘致癌物。
