Amini-Sereshki L
Am J Physiol. 1977 May;232(5):R190-7. doi: 10.1152/ajpregu.1977.232.5.R190.
Regions containing heat gain tonic inhibitory areas in mesencephalon and upper pons were studied using topical microinjection of a local anesthetic. This inhibition was compared in the mesencephalic decerebrated and intact animals. In mesencephalic animals that failed to shiver, bilateral injections of procaine into the ventromedial pontine tegmental areas released some heat gain responses and in intact anesthetized cats injections in the same regions increased intensity of shivering. These effects on inhibitory areas are reversible and can be repeated in the same preparation several times. Permanent effects were obtained by electrolytic lesions or by the local microinjections of 1% osmic acid. In summary, it is shown, by means of microinjection of local anesthetic, that a tonic inhibitory area located in the ventromedial pontine reticular formation completely inhibits shivering in the mesencephalic decerebrate preparation and partially inhibits shivering in the intact anesthetized preparation.
采用局部麻醉药局部微量注射的方法，对中脑和脑桥上段含有产热紧张性抑制区的区域进行了研究。在中脑去大脑动物和完整动物中对这种抑制作用进行了比较。在未能发生寒战的中脑动物中，向脑桥腹内侧被盖区双侧注射普鲁卡因可释放出一些产热反应，而在完整的麻醉猫中，在相同区域注射则可增加寒战强度。这些对抑制区的作用是可逆的，并且可以在同一实验标本上重复多次。通过电解损伤或局部微量注射1%锇酸可获得永久性作用。总之，通过局部麻醉药微量注射表明，位于脑桥腹内侧网状结构的紧张性抑制区在中脑去大脑标本中可完全抑制寒战，在完整的麻醉标本中可部分抑制寒战。
