Amini-Sereshki L
Am J Physiol. 1977 May;232(5):R198-202. doi: 10.1152/ajpregu.1977.232.5.R198.
Regions containing areas and pathways mediating heat gain responses in the mesencephalon and upper pons and in the medulla were studied using topical microinjection of a local anesthetic. These facilitatory areas and pathways were compared in the decerebrated and intact cats. In lower pontine preparations shivering was abolished by bilateral injections of procaine into the lateral medullary reticular formation. Injections into the same areas in the intact anesthetized cat resulted in the cessation of shivering. These effects on facilitatory areas are reversible and can be repeated in the same preparation several times. Permanent effects were obtained by electrolytic lesions or by the local microinjections of 1% osmic acid. In summary it shown, by means of microinjection of local anesthetic, that the pathways mediating shivering in the intact and lower pontine cats are located in the same area in lateral reticular formation of pons and medulla.
利用局部麻醉剂的局部微量注射，对中脑、脑桥上段以及延髓中包含介导产热反应的区域和通路进行了研究。在去大脑猫和完整猫中对这些易化区和通路进行了比较。在脑桥下段制备中，通过向外侧延髓网状结构双侧注射普鲁卡因可消除寒战。在完整麻醉猫的相同区域注射会导致寒战停止。这些对易化区的作用是可逆的，并且可以在同一制备中重复多次。通过电解损伤或局部微量注射1%锇酸可获得永久性效应。总之，通过局部麻醉剂的微量注射表明，完整猫和脑桥下段猫中介导寒战的通路位于脑桥和延髓外侧网状结构的同一区域。
