Reynen K, Bachmann K
Medizinische Klinik II Universität Erlangen-Nürnberg.
Z Kardiol. 1996 May;85(5):299-305.
Today, an increasing number of old and very old patients is referred for invasive cardiovascular procedures. At our institution, cardiac catheterization has been performed in 82 patients 80 years of age or older (50 m, 32 f; mean age 82 +/- 2 years) during the last 11 years; in 70 patients, because of clinically proven or suspected coronary heart disease, and in 12 patients, because of heart valve disease. In comparison with younger patients, elderly patients with coronary heart disease more often presented with unstable angina, or had multivessel disease and reduced ejection fractions. PTCA (n = 25) and bypass grafting (n = 7) aimed at revascularization in 32 patients; in 38 patients, medical treatment was continued. Furthermore, valve replacement (n = 7) or valvuloplasty (n = 1) were judged to be indicated in 8 of the 12 patients with heart valve disease. Diagnostic procedure was more frequently burdened with serious complications in elderly than in younger patients (5/82 versus 3/300, p < 0.01). During follow-up of 25 +/- 23, median 21 months, cardiovascular events were significantly less frequent in patients with coronary heart disease who had undergone revascularization procedures than in those with medical therapy (2/29 versus 9/36; p = 0.05); more revascularized patients were free of angina at the time of reevaluation. Thus, risks of invasive diagnostic procedures are increased in very old patients. Diagnostics, however, result in therapeutical consequences, revascularization obviously improves symptomatology and prognosis in patients at extremely advanced age suffering from coronary heart disease.
如今,越来越多的老年及高龄患者被转诊接受侵入性心血管手术。在我们机构,过去11年中,80岁及以上的患者接受了心脏导管插入术(50名男性,32名女性;平均年龄82±2岁);70名患者是因为临床证实或疑似冠心病,12名患者是因为心脏瓣膜疾病。与年轻患者相比,老年冠心病患者更常表现为不稳定型心绞痛,或患有多支血管病变且射血分数降低。25例患者接受了经皮冠状动脉腔内血管成形术(PTCA),7例患者接受了搭桥手术,旨在为32例患者进行血管重建;38例患者继续接受药物治疗。此外,12例心脏瓣膜疾病患者中有8例被判定适合进行瓣膜置换术(7例)或瓣膜成形术(1例)。与年轻患者相比,老年患者的诊断性操作更常出现严重并发症(5/82对3/300,p<0.01)。在25±23个月(中位数21个月)的随访中,接受血管重建手术的冠心病患者心血管事件的发生率明显低于接受药物治疗的患者(2/29对9/36;p=0.05);更多接受血管重建的患者在重新评估时无心绞痛症状。因此,高龄患者进行侵入性诊断操作的风险增加。然而,诊断会带来治疗后果,血管重建显然改善了患有冠心病的高龄患者的症状和预后。