Herzenberg A M, Lien J, Magil A B
Department of Pathology and Laboratory Medicine, St. Paul's Hospital, Vancouver, BC, Canada.
Am J Kidney Dis. 1996 Jul;28(1):128-31. doi: 10.1016/s0272-6386(96)90141-9.
Seven cases of nonamyloid heavy chain (gamma chain) deposition disease have been previously reported. We describe one case of a 79-year-old woman presenting with proteinuria and microscopic hematuria whose renal biopsy showed nodular glomerulosclerosis with deposition of gamma3 heavy chains and complement in the glomeruli and tubular basement membranes with no associated light chain deposition. The patient did not have multiple myeloma. This case is unique in that in all previously reported cases of heavy chain deposition disease the gamma chain subtype has been either gamma1 or gamma4.
此前已有7例非淀粉样重链（γ链）沉积病的报道。我们描述了1例79岁女性患者，其表现为蛋白尿和镜下血尿，肾活检显示结节性肾小球硬化，γ3重链和补体沉积于肾小球及肾小管基底膜，无相关轻链沉积。该患者无多发性骨髓瘤。此病例的独特之处在于，在所有先前报道的重链沉积病病例中，γ链亚型均为γ1或γ4。
