Russell R, Reynolds F
Department of Anaesthetics, St Thomas' Hospital, London.
Anaesthesia. 1996 Mar;51(3):266-73. doi: 10.1111/j.1365-2044.1996.tb13645.x.
Labouring women were randomly allocated to receive epidural infusions during labour of either 0.125% plain bupivacaine (n = 200) or a combination of 0.0625% bupivacaine with either 2.5 micrograms.ml-1 fentanyl or 0.25 micrograms.ml-1 sufentanil (n = 199) each starting at 12 ml.h-1 and adjusted as necessary to maintain analgesia. The dose of bupivacaine, both hourly (p < 0.001) and total (p < 0.001), was significantly lower in the group receiving the combination. Motor block was significantly less common and less severe in the combination group (p < 0.001). These reductions did not result in a significant increase in spontaneous deliveries. Maternal satisfaction with first (p < 0.001) and second stage analgesia (p < 0.001) was significantly increased in the combination group. The addition of opioid to the epidural infusion did not reduce the incidence of perineal pain. There were no significant differences between the groups in neonatal outcome or the incidence of early postnatal symptoms.
分娩妇女被随机分配在分娩期间接受硬膜外输注,其中一组输注0.125%的单纯布比卡因(n = 200),另一组输注0.0625%布比卡因与2.5微克/毫升芬太尼或0.25微克/毫升舒芬太尼的组合(n = 199),两组均从12毫升/小时开始输注,并根据需要进行调整以维持镇痛效果。接受联合用药的组中,布比卡因的每小时剂量(p < 0.001)和总剂量(p < 0.001)均显著较低。联合用药组运动阻滞的发生率显著更低且程度更轻(p < 0.001)。这些降低并未导致自然分娩率显著增加。联合用药组产妇对第一产程(p < 0.001)和第二产程镇痛(p < 0.001)的满意度显著提高。在硬膜外输注中添加阿片类药物并未降低会阴疼痛的发生率。两组在新生儿结局或产后早期症状发生率方面无显著差异。