Brown M T, Montgomery W W
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA.
Ann Otol Rhinol Laryngol. 1996 Aug;105(8):624-7. doi: 10.1177/000348949610500807.
Granulation tissue formation and contraction is inevitable during the healing of open wounds. The presence of infection and a foreign body, such as a silicone airway prosthesis or other tracheotomy tube, magnifies this response. In airway reconstruction, wound contraction secondary to chronic inflammation is a liability. Cultures of granulation tissue were taken from 12 patients with silicone cannulas of T-Tubes. Polymicrobial colonization predominated, with variable combinations of gram-positive, gram-negative, and anaerobic organisms being present. On the basis of sensitivity data, amoxicillin-clavulanate potassium and ciprofloxacin hydrochloride were chosen as empirical antimicrobials. Anecdotally, impressive decreases in the quantity of granulation tissue were seen. We recommend a prospective trial to more accurately define the role of antibiotics in this setting.
开放性伤口愈合过程中，肉芽组织形成和收缩是不可避免的。感染以及异物（如硅胶气道假体或其他气管切开导管）的存在会放大这种反应。在气道重建中，慢性炎症继发的伤口收缩是一个不利因素。从12例使用T型管硅胶插管的患者身上采集了肉芽组织培养物。以多种微生物定植为主，存在革兰氏阳性菌、革兰氏阴性菌和厌氧菌的不同组合。根据药敏数据，选择阿莫西林克拉维酸钾和盐酸环丙沙星作为经验性抗菌药物。据传闻，可见肉芽组织数量明显减少。我们建议进行一项前瞻性试验，以更准确地确定抗生素在这种情况下的作用。
