Tang J T, Yamazaki H, Nishimoto N, Inoue T, Nose T, Koizumi M, Tanaka E, Ogata A, Yoshizaki K, Inoue T
Department of Radiation Oncology, Osaka University Medical School, Japan.
Anticancer Res. 1996 Jul-Aug;16(4A):2005-8.
To determine the inflammatory state of cervical cancer after radiotherapy, we examined serum interleukin 6 levels (sIL-6) and C-reactive protein (CRP) before and after radiation therapy in sixteen patients with cervical cancer. External radiation therapy did not cause changes in sIL-6 and CRP during the examined periods. On the other hand, brachytherapy caused transient elevation of sIL-6 on the day after treatment by 6.39 +/- 1.89 pg/ml to 13.41 +/- 2.34 pg/ml (p < 0.05) while CRP did not show any significant change. Therefore, brachytherapy would induce a small inflammatory reaction. However, we confirmed that radiotherapy is a less invasive treatment than surgery from the point of view of cytokine related inflammation.
为了确定宫颈癌放疗后的炎症状态，我们检测了16例宫颈癌患者放疗前后的血清白细胞介素6水平（sIL-6）和C反应蛋白（CRP）。在检查期间，外照射放疗未引起sIL-6和CRP的变化。另一方面，近距离放疗导致治疗后第1天sIL-6短暂升高，从6.39±1.89 pg/ml升至13.41±2.34 pg/ml（p<0.05），而CRP未显示任何显著变化。因此，近距离放疗会诱发轻微的炎症反应。然而，从细胞因子相关炎症的角度来看，我们证实放疗是一种比手术侵入性更小的治疗方法。
