Luscinskas F W, Gimbrone M A
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Annu Rev Med. 1996;47:413-21. doi: 10.1146/annurev.med.47.1.413.
Peripheral blood leukocytes interact with the vascular endothelium in a wide range of physiologic and pathophysiologic situations. A current working concept is that activation of vascular endothelium is an important event during the inflammatory response, conferring spatial and temporal localization and leukocyte-type selectivity to the recruitment process. This chapter highlights recent advances in our understanding of the endothelial-dependent molecular mechanisms that mediate recruitment of mononuclear leukocytes (lymphocytes and monocytes) and discusses these advances in the context of chronic inflammatory diseases and their potential therapeutic interventions.
在多种生理和病理生理情况下，外周血白细胞与血管内皮相互作用。当前的一个工作概念是，血管内皮的激活是炎症反应期间的一个重要事件，它为募集过程赋予空间和时间定位以及白细胞类型选择性。本章重点介绍了我们在理解介导单核白细胞（淋巴细胞和单核细胞）募集的内皮依赖性分子机制方面的最新进展，并在慢性炎症性疾病及其潜在治疗干预的背景下讨论了这些进展。
