[三例药物性溶血尿毒综合征]
[Three cases of drug-induced hemolytic uremic syndrome].
作者信息
Tohda S, Shiigai T, Jibiki M, Aoi T, Ueda Y, Kawasaki T, Kurokawa H, Nara N
机构信息
Department of Internal Medicine, Toride Kyodo Hospital, Japan.
出版信息
Gan To Kagaku Ryoho. 1996 Feb;23(3):361-4.
We report three cases of drug-induced hemolytic uremic syndrome (HUS). Three patients with advanced gastrointestinal cancer underwent a curative operation and adjuvant chemotherapy with Mitomycin C (MMC), 5FU and Ara-C. Later, progressive anemia, thrombocytopenia, renal dysfunction and elevation of serum LDH were recognized. A diagnosis of HUS was made. As they had no symptoms of infectious diseases or relapse of cancer, the cause of HUS was thought to be MMC. Treatment with antiplatelet drugs and fresh frozen plasma was effective for two patients. However, one patient died of pulmonary edema.
我们报告了三例药物性溶血性尿毒症综合征（HUS）。三名晚期胃肠道癌患者接受了根治性手术，并使用丝裂霉素C（MMC）、5-氟尿嘧啶（5FU）和阿糖胞苷（Ara-C）进行辅助化疗。后来，患者出现进行性贫血、血小板减少、肾功能不全以及血清乳酸脱氢酶（LDH）升高。确诊为HUS。由于他们没有传染病症状或癌症复发迹象，HUS的病因被认为是MMC。两名患者使用抗血小板药物和新鲜冷冻血浆治疗有效。然而，一名患者死于肺水肿。
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