Beletskaia L V, Zhbanova L B, Zaĭdenov V A, Kurenkova L G, Riaboshtanova E I
Arkh Patol. 1996 Mar-Apr;58(2):45-9.
Summary. Vinculin, the protein of cardiomyocyte cytoskeleton in the myocardium of patients with a dilated cardiomyopathy and ischemic heart disease, was revealed by means of monoclonal antibodies and by a method of indirect immunofluorescence. Cytoskeleton of patients with dilated cardiomyopathy is disorganized, hypertrophic and contains greater amounts of vinculin than cytoskeleton of normal cardiomyocytes. This most likely negatively influences cell contractile capacity. The vinculin content was also higher in cardiomyocyte cytoskeleton of patients with ischemic heart disease but at a less degree than in patients with dilated cardiomyopathy.
摘要。利用单克隆抗体和间接免疫荧光法，在扩张型心肌病和缺血性心脏病患者的心肌中发现了纽蛋白，它是心肌细胞细胞骨架的一种蛋白质。扩张型心肌病患者的细胞骨架紊乱、肥大，且比正常心肌细胞的细胞骨架含有更多的纽蛋白。这很可能对细胞收缩能力产生负面影响。缺血性心脏病患者心肌细胞骨架中的纽蛋白含量也较高，但程度低于扩张型心肌病患者。
