Muto M, Fujikura Y, Hamamoto Y, Ichimiya M, Ohmura A, Sasazuki T, Fukumoto T, Asagami C
Department of Dermatology, Yamaguchi University School of Medicine, Ube, Japan.
Australas J Dermatol. 1996 May;37 Suppl 1:S54-5. doi: 10.1111/j.1440-0960.1996.tb01087.x.
Monoclonal antibodies directed against type 12 Group A streptococcal cell wall antigens cross-react with nuclei and cytoplasm of cells from skin and synovium from controls, uninvolved skin of psoriatics and psoriatic plaques. Patients with psoriasis had high serum titres of antibody against the M12 (C-region) streptococcal antigen compared to controls. An abnormal immune response directed against a "self' antigen after initiation by Group A streptococcal infection may play an important role in the exacerbation or development of psoriasis.
针对12型A组链球菌细胞壁抗原的单克隆抗体与对照组、银屑病患者未受累皮肤及银屑病斑块的皮肤和滑膜细胞的细胞核及细胞质发生交叉反应。与对照组相比，银屑病患者血清中抗M12（C区）链球菌抗原的抗体滴度较高。A组链球菌感染引发针对“自身”抗原的异常免疫反应可能在银屑病的加重或发展中起重要作用。
