磷脂酰丝氨酸介导的T细胞与内皮细胞的黏附。
Phosphatidylserine-mediated adhesion of T-cells to endothelial cells.
作者信息
Qu J, Conroy L A, Walker J H, Wooding F B, Lucy J A
机构信息
Department of Cellular Physiology, Babraham Institute, Cambridge, UK.
出版信息
Biochem J. 1996 Jul 15;317 ( Pt 2)(Pt 2):343-6. doi: 10.1042/bj3170343.
Abstract
Phosphatidylserine was exposed on the surface of human umbilical endothelial cells (ECV304) a few minutes after adding thrombin in vitro, as monitored by prothrombinase assays with and without annexin V. Jurkat T cells adhered to the thrombin-treated cells. The adhesion was inhibited by annexin V, indicating that it was mediated by exposed phosphatidylserine on the endothelial cells.
摘要
体外加入凝血酶几分钟后，通过有无膜联蛋白V的凝血酶原酶测定监测发现，磷脂酰丝氨酸暴露于人类脐静脉内皮细胞（ECV304）表面。Jurkat T细胞黏附于经凝血酶处理的细胞。这种黏附被膜联蛋白V抑制，表明其是由内皮细胞上暴露的磷脂酰丝氨酸介导的。
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