Farbiszewski R, Bielawski K, Bielawska A, Sobaniec W
Department of Analytical Chemistry, Medical Academy, Bialystok, Poland.
Acta Neurobiol Exp (Wars). 1995;55(4):253-8. doi: 10.55782/ane-1995-1084.
The antioxidant enzymatic system in brain hypoperfusion/reperfusion model in rats after spermine administration was evaluated. Incomplete cerebral ischemia/reperfusion induced by temporal occlusion of common carotid arteries caused a decrease in the activities of superoxide dismutase and glutathione reductase as well as total and free sulfhydryl groups, while thiobarbituric acid-reactive substances became elevated. Administration of spermine after the reperfusion led to restoring all above parameters to normal values. Protective effect of spermine in transiently hypoperfused and subsequently reperfused rat brain is briefly discussed.
评估了给予精胺后大鼠脑缺血/再灌注模型中的抗氧化酶系统。颈总动脉短暂闭塞诱导的不完全脑缺血/再灌注导致超氧化物歧化酶和谷胱甘肽还原酶的活性以及总巯基和游离巯基减少，而硫代巴比妥酸反应性物质升高。再灌注后给予精胺可使上述所有参数恢复到正常水平。简要讨论了精胺对短暂灌注不足随后再灌注的大鼠脑的保护作用。
