Farbiszewski R, Chwiecko M, Ustymowicz J
Department of Analytical Chemistry, Medical Academy, Bialystok, Poland.
Eur J Pharmacol. 1994 Apr 4;270(2-3):263-5. doi: 10.1016/0926-6917(94)90070-1.
The antioxidant enzymatic system in the ischemia/reperfusion induced brain injury in rats after U-74389G administration was evaluated. Ischemia/reperfusion caused a decrease in the activities of superoxide dismutase and glutathione reductase, as well as of total and free sulfhydryl groups, while thiobarbituric acid-reactive substances became elevated. Administration of U-74389G lead to restoring to normal values of all above parameters. Protective effect of the drug in ischemia/reperfusion induced brain injury has been suggested.
